Elastic physiological patch

ABSTRACT

An elastic physiological patch includes a patch assembly and an implant assembly. The patch assembly includes an electronic device, and a soft patch body defining a chamber for receiving the electronic device. The implant assembly is mountable to the electronic device and includes an implant which is capable of being driven to partially pass through the patch body and which is adapted to be implanted in the skin of a subject. The implant and the patch body cooperatively seal the chamber.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation application of U.S. patentapplication Ser. No. 16/519,622, filed on Jul. 23, 2019, which claimspriority to Taiwanese Patent Application No. 107125993, filed on Jul.27, 2018.

FIELD

The disclosure relates to a patch, more particularly to a physiologicalpatch suitable for use on a human body.

BACKGROUND

Referring to FIGS. 1 and 2, a conventional sensor patch 1, as disclosedin U.S. Pat. No. 7,899,511B2, includes an adhesive pad 11 for adheringto the skin of a user, a base 12 adhered to the adhesive pad 11, amounting seat 13 disposed in the base 12, a sensor installed on themounting seat 13, and an electronic device 15 disposed on the base 12and electrically connected to the sensor 14. However, during use of theconventional sensor patch 1, an external liquid (such as a body liquid)often penetrates into the base 12 through a hole in the adhesive pad 11or into the mounting seat 13 along the sensor 14, causing damage to theelectronic device 15. To avoid this phenomenon, a sealant is coated on ajunction between the sensor 14 and the mounting seat 13 and a junctionbetween the mounting seat 13 and the base 12 during assembly, and isthen heated to liquefy and penetrate into gaps, thereby achieving aclosed waterproof effect. In practice, the sealant may be replaced by anultrasonic welding or O-ring.

However, the aforementioned waterproof sealing method has itsdisadvantages. In terms of applying the sealant, it is required to heatthe sealant after it is coated on each junction, so that the process israther cumbersome, and the assembly is more difficult. The ultrasonicwelding also has the same cumbersome assembly problem as that of thesealant, and its fusion temperature may damage the electronic device 15.In O-ring, the sealing effect is achieved by pressing two objectstightly against the O-ring, so that the O-ring is more suitable for usein sealing hard objects, such as the base 12 and the mounting seat 13.However, because the physical strength of the sensor 14 is low, a tightpressing force may increase the risk of damage of the sensor 14, so thatthe O-ring is not suitable for use in sealing the sensor 14.

SUMMARY

Therefore, an object of the present disclosure is to provide an elasticphysiological patch that is capable of alleviating at least one of thedrawbacks of the prior art.

According to this disclosure, an elastic physiological patch includes apatch assembly and an implant assembly. The patch assembly includes anelectronic device, and a soft patch body defining a chamber forreceiving the electronic device. The implant assembly is mountable tothe electronic device and includes an implant which is capable of beingdriven to partially pass through the patch body and which is adapted tobe implanted in the skin of a subject. The implant and the patch bodycooperatively seal the chamber.

BRIEF DESCRIPTION OF THE DRAWINGS

Other features and advantages of the present disclosure will becomeapparent in the following detailed description of the embodiments withreference to the accompanying drawings, of which:

FIG. 1 is an exploded perspective view of a conventional sensor patchdisclosed in U.S. Pat. No. 7,899,511B2;

FIG. 2 is an assembled sectional side view of the conventional sensorpatch of FIG. 1;

FIG. 3 is a perspective view of an elastic physiological patch accordingto the first embodiment of the present disclosure;

FIG. 4 is a front sectional view of the first embodiment;

FIG. 5 is a top sectional view of the first embodiment;

FIG. 6 is a block diagram of a transmitting unit of the firstembodiment;

FIG. 7 is a bottom view of a patch body of the first embodiment;

FIG. 8 is another front sectional view of the first embodiment,illustrating how an implant assembly of the first embodiment is disposedin a guide needle of an insertion device and is aligned with a patchassembly of the first embodiment;

FIG. 9 is a view similar to FIG. 8, but with the guide needle togetherwith the implant assembly extending through the patch assembly;

FIG. 10 illustrates how the guide needle together with the implantassembly is disposed in the patch assembly;

FIG. 11A is a fragmentary top view of an elastic physiological patchaccording to the second embodiment of the present disclosure,illustrating a trigger mechanism of the implant assembly in a stateprior to being triggered;

FIG. 11B is a view similar to FIG. 11A, but with the trigger mechanismbeing triggered to push a guide needle together with an implant disposedin the guide needle;

FIG. 11C is a view similar to FIG. 11B, but with the guide needle beingretracted leaving the implant;

FIG. 12A is a side sectional view of the second embodiment, illustratingthe trigger mechanism prior to being triggered;

FIG. 12B is a view similar to FIG. 12A, but with the trigger mechanismbeing triggered to push the guide needle together with the implant;

FIG. 12C is a view similar to FIG. 12B, but with the guide needle beingretracted leaving the implant;

FIG. 13 is a front sectional view of an elastic physiological patchaccording to the third embodiment of the present disclosure prior toinsertion of the implant assembly into the patch assembly;

FIG. 14 is a view similar to FIG. 13, but with the implant assemblyinserted into the patch assembly;

FIG. 15 is a front sectional view of an elastic physiological patchaccording to the fourth embodiment of the present disclosure;

FIG. 16A is a fragmentary top view of the fourth embodiment,illustrating the trigger mechanism prior to being triggered;

FIG. 16B is a view similar to FIG. 16A, but with the trigger mechanismin a state after being triggered;

FIG. 17A is a side sectional view of the fourth embodiment, illustratingthe trigger mechanism prior to being triggered;

FIG. 17B is a view similar to FIG. 17A, but with the trigger mechanismin the state after being triggered;

FIG. 18 is a front sectional view of an elastic physiological patchaccording to the fifth embodiment of the present disclosure; and

FIG. 19 is a front sectional view of an elastic physiological patchaccording to the sixth embodiment of the present disclosure.

DETAILED DESCRIPTION

Before the present disclosure is described in greater detail withreference to the accompanying embodiment, it should be noted herein thatlike elements are denoted by the same reference numerals throughout thedisclosure.

Referring to FIGS. 3 to 6, an elastic physiological patch 100 accordingto the first embodiment of the present disclosure is suitable to beadhered on the skin of a subject, such as a human body, for use inmeasuring the glucose level of the human body. The elastic physiologicalpatch 100 includes a patch assembly 2 and an implant assembly 3.

The patch assembly 2 includes an electronic device 4 and a soft patchbody 5. The electronic device 4 includes a circuit board 41, atransmitting unit 42, and a battery 43 for supplying power to thetransmitting unit 42. The circuit board 41 has two spaced-apart signalreading areas 411 for receiving signals, and a through hole 412. Thecircuit board 41 may be made of a soft or hard board. In order to obtaina better mechanical strength, the circuit board 41 of this embodiment ismade of a hard board.

The transmitting unit 42 is disposed on the circuit board 41 forreceiving electrical signals from the signal reading areas 411 andoutputting a corresponding glucose level signal. The transmitting unit42 includes a signal amplifier 421, an analog digital signal converter422, a processor 423 and a transmitter 424 interconnected to oneanother. The signal amplifier 421 is used for receiving and amplifyingthe electrical signals. The analog digital signal converter 422 convertsthe amplified electrical signals into a corresponding digital signal.The processor 423 converts the corresponding digital signal into aglucose level signal. The transmitter 424 is used for transmitting theglucose level signal to an external receiving device 91. Those skilledin the art may adjust the internal configuration of the transmittingunit 42 according to the requirement, and is not limited to what isdisclosed herein.

Referring to FIG. 7, in combination with FIG. 4, the patch body 5 coversthe electronic device 4, has a disk shape, and is made of thermosettingor thermoplastic elastomer. The elastomer has an inject-ion temperatureranging from 140 to 170° C. Preferably, the elastomer is selected from agroup consisting of silica gel, silicone, polyurethane (PU), and acombination thereof. The patch body 5 has a bottom wall 51, a top wall52 opposite and connected to the bottom wall 51 and cooperating with thesame to define therebetween a chamber 53 for receiving the electronicdevice 4, and two spaced-apart electrical connection pieces 54. The topwall 52 has a curved top surface 521. The bottom wall 51 is circular,and has an adhering surface 511 for being adhered to the skin of thehuman body, and a plurality of long-strip grooves 512 and a plurality ofring-shaped grooves 513 formed in the adhering surface 511. Thelong-strip grooves 512 are radially extending grooves. The ring-shapedgrooves 513 are arranged concentrically. The electrical connectionpieces 54 are disposed in the chamber 53, and each electrical connectionpiece 54 contains a conductive material for electrical connection with arespective one of the signal reading areas 411 of the circuit board 41.

To make the patch assembly 2, the electronic device 4 is first placed ina mold (not shown), after which the signal reading areas 411 of thecircuit board 41 are injected with conductive silicone to use as theelectrical connection pieces 54 of the patch body 5, followed byinjection of silicone to completely cover the electronic device 4.Another way of making the patch assembly 2 is to weld two metal elasticpieces to the respective signal reading areas 411 firstly, after whichthe electronic device 4 is placed in the mold, followed by injection ofsilicone to completely cover the electronic device 4. Portions of themetal elastic pieces are exposed from the silicone for electricalconnection with the implant assembly 3. The metal elastic pieces may bereplaced by silicone conductive strips. The making of the patch assembly2, apart from the foregoing methods, may also use other manufacturingmethods, as long as the patch body 5 can integrally and completelyencapsulate the electronic device 4, any method is acceptable.

Referring to FIGS. 8 and 9, in combination with FIG. 4, to use theelastic physiological patch 100, the patch assembly 2 is first placed onthe skin of a human body, after which the implant assembly 3 is mountedto the patch assembly 2 and is connected to the electrical connectionpieces 54 of the patch body 5 to electrically connect with theelectronic device 4. The implant assembly 3 includes an implant 31. Inthis embodiment, the implant 31 is a sensor for measuring glucose level.The implant or sensor has a signal output end 312 and a sensing end 313.The sensor 31 is linear, and has two sides each of which is providedwith an electrode for electrical connection with the respectiveelectrical connection piece 54.

In this embodiment, a mounting method of the implant assembly 3 is todetachably position the sensor 31 firstly into a hollow guide needle 901of an insertion device 90 that is disposed on an outer side of the patchassembly 2, after which the guide needle 901 is aligned with the throughhole 412 (see FIG. 8) in the circuit board 41, followed by thetriggering of the guide needle 901, so that the guide needle 901together with the sensor 31 is driven to pass in sequence from the outerside of the patch assembly 2 through the top wall 52 of the patch body5, between the electrical connection pieces 54, the through hole 412 andthe bottom wall 51 (see FIG. 9), and into the skin of the human body.Afterwards, the guide needle 901 is withdrawn by the insertion device 90for leaving the signal output end 312 of the sensor 31 fixed by thepatch assembly 2 and the sensing end 313 of the sensor 31 implanted inthe skin of the human body, as shown in FIG. 4.

Referring to FIG. 10, in combination with FIG. 4, another mountingmethod of the implant assembly 3 is to combine the sensor 31 with theguide needle 901 firstly, after which they are directly inserted intothe chamber 53 of the patch assembly 2. To attach the elasticphysiological patch 100 to the human body, the patch assembly 2 is firstadhered to the skin of the human body, after which the guide needle 901together with the sensor 31 is driven to pierce through the bottom wall51 of the patch body 5 into the human body through the insertion device(see FIG. 9), and then the guide needle 901 is pulled out by theinsertion device 90 for leaving the sensor 31 implanted in the skin ofthe human body. Generally, the insertion device 90 includes an implantholder (not shown) and a guide needle holder (not shown). When theimplant holder is pressed downward, because there is a correspondingstructure inside the implant holder for covering the guide needleholder, the guide needle holder can move along with the implant holder,and then withdraw the guide needle leaving the implant in the skin ofthe human body. Since the implant holder and the guide needle holder aretwo independent components, and since only the guide needle holder isprovided with a return spring for returning the guide needle holder toits original position, only the guide needle connected to the guideneedle holder can be withdrawn leaving the implant in the skin of thehuman body. For details of the structure and operation of the insertiondevice, reference may be referred to U.S. Patent Application PublicationNo. 2017/0290533A1. Since the insertion device 90 is known in the art,the present disclosure is not limited to the above-mentioned example andonly illustrates the guide needle 901 and the sensor 31 disposed in theguide needle 901 in FIG. 10. It is worth to mention herein that theimplant operation may not use the insertion device 90, and may be donemanually, as long as the guide needle 901 can be inserted and pulled outto similarly achieve the implantation of the sensor 31.

Since the patch body 5 is integrally formed and encapsulates theelectronic device 4, the electronic device 4 can be well protected.Further, by virtue of the material characteristics of the patch body 5,when the guide needle 901 pierces through and is withdrawn from the topwall 52 of the patch body 5, the patch body 5 will rebound and extrude apassage 523 pierced by the guide needle 901 to achieve sealing andwaterproof effects; and when the guide needle 901 pierces through and iswithdrawn from the bottom wall 51 of the patch body 5, the patch body 5will rebound and tightly hold the implant 31 and will cooperate with theimplant 31 to seal the chamber 53. That is, apart from the portionpierced by the guide needle 901, the patch body 5 does not have anyother hole, so that it has an excellent isolating effect. It is worth tomention herein that to take into account a tight sealing effect betweenthe implant 31 and the bottom wall 51 of the patch body 5 and a mountingresistance needed to overcome when the guide needle 901 together withthe implant or sensor 31 pass through the patch body 5, the thickness ofthe bottom wall 51 is ranged from 0.2 mm to 1 mm. Preferably, thethickness of the bottom wall 51 is ranged from 0.2 mm to 0.5 mm toensure that the guide needle 901 together with the sensor 31 cansmoothly pass through the bottom wall 51 and the sensor 31 can have asufficient contact area with the bottom wall 51 when the guide needle901 is withdrawn so as to block moisture from entering the chamber 53,thereby achieving an effective waterproof.

From the foregoing, the advantages of this disclosure can be summarizedas follows:

1. When the implant or sensor 31 of the implant assembly 3 is disposedin the patch assembly 2, the assembly of the physiological patch 100 iscompleted and is convenient. Moreover, because the patch body 5 cancompletely cover or encapsulate the electronic device 4 and can tightlyhold the implant 31, the patch body 5 can cooperate with the implant 31to achieve sealing and waterproof effects of the physiological patch100.

2. The making of the patch assembly 2 is easy. Just by injecting softmaterial into a mold to cover the electronic device 4 and followed bysolidification, the making of the patch assembly 2 is completed.Further, the electrical connection pieces 54 can be formed on therespective signal reading areas 411 of the electronic device 4 by simplypouring adhesive in batches, so that there is no need for additionalprovision of conductive components. Hence, the manufacturing cost can bereduced.

3. The material of the patch body 5 is selected from elastomers havingan injection temperature ranging from 140 to 170° C. This temperaturerange can ensure that the electronic device 4 encapsulated by the patchbody 5 will not be damaged.

4. The patch body 5 is made of a soft material, so that it can followthe bends and curves of the skin of the human body so as to adhereclosely to the skin, thereby reducing the possibility of removaltherefrom.

5. When the patch body 5 is adhered to the skin of the human body, thelong-strip grooves 512 and the ring-shaped grooves 513 thereof canincrease permeability, thereby reducing the possibility of skinallergies.

Referring to FIGS. 11A to 11C and 12A to 12C, the second embodiment ofthe elastic physiological patch 100′ according to this disclosure isgenerally identical to the first embodiment, and differs in that, in thesecond embodiment, the implant assembly 3 is disposed in the chamber 53and further includes two conductive members 32 and an insertion device33, and the electronic device 4 further includes a guide member 46disposed on the circuit board 41. The electrical connection pieces 54(see FIG. 4) are dispensed herewith.

The conductive members 32 are respectively disposed on the signalreading areas 411.

The insertion device 33 includes a trigger mechanism 331 and a hollowguide needle 332. The trigger mechanism 331 is operable to drive theaction of the guide needle 332, and includes a track 333, a movable seat334, a pivot arm assembly 335, and a torsion spring 336. The movableseat 334 is slidably disposed on the track 333. The guide needle 332 isconnected to the movable seat 334. The pivot arm assembly 335 iscomposed of two pivot arms (337 a, 337 b) pivoted to each other. Thepivot arm (337 a) has two opposite ends respectively pivoted to thepivot arm (337 b) and the movable seat 334. The pivot arm (337 b) hastwo opposite ends respectively pivoted to the pivot arm (337 a) and thetorsion spring 336. The implant or sensor 31 is detachably positioned inthe guide needle 332.

Prior to activation of the trigger mechanism 331, as shown in FIGS. 11Aand 12A, the movable seat 334 is held immovably on the track 333. Thetrack 333 can be limited by any position limiting mechanism.Furthermore, the movable seat 334 is coupled to the pivot arm (337 a) soas to be temporarily stopped and then driven by the pivot arm assembly335 cooperated with the torsion spring 336. As shown in FIGS. 11B and12B, as the movable seat 334 is released, the torsion spring 336 willrotate to drive the action of the pivot arm assembly 335, which in turnwill push the movable seat 334 to move toward the conductive members 32.As the movable seat 334 moves toward the conductive members 32, theguide needle 332 together with the sensor 31 will pass through betweenthe conductive members 32, and is guided by the guide member 46 to movetoward and pierce through the bottom wall 51 of the patch body 5 and theskin of the human body. As shown in FIGS. 11C and 12C, when the torsionspring 336 is continuously rotated, the movable seat 334 is pulled backto its original position through the action of the pivot arm assembly335, and retracts the guide needle 332 leaving the sensor 31 implantedin the skin of the human body. The conductive members 32 can clamp thesensor 31 through its own resiliency to electrically connect with thesame.

To ensure the operation of the trigger mechanism 331, a cover body 338(see FIGS. 12A to 12C) can be further provided for covering theinsertion device 33 and prevent the elastic body from flowing into thetrigger mechanism 331, which may cause its damaged, during the making ofthe patch body 5. The track 333 can be formed on a bottom wall of thecover body 338, as shown in FIG. 12A. Actually, the track 333 iscooperated with the movable seat 334 and can be mounted to any type ofsubstrate.

The elastic physiological patch 100′ of the second embodiment not onlycan achieve the same effect as that of the first embodiment, but also,because the implant assembly 3 is disposed in the chamber 53 of thepatch body 5 so that there is no need to cooperate with the externalinsertion device (see FIG. 8), the implant assembly 3 can beconveniently assembled to the human body. Hence, it is better than thefirst embodiment.

Referring to FIGS. 13 and 14, the third embodiment of the elasticphysiological patch 100″ according to this disclosure is generallyidentical to the first embodiment, and differs in that, in the thirdembodiment, the implant assembly 3 further includes a conductive member32, and the top wall 52 of the patch body 5 has a precut hole 522.

The conductive member 32 is inserted into the signal output end 312 ofthe sensor 31, and has an outer diameter slightly larger than a diameterof the precut hole 522, so that the conductive member can be pressfittedand embedded in the precut hole 522. Preferably, the outer diameter ofthe conductive member 32 is larger than the diameter of the precut hole522 by 0.1 mm to 1 mm.

The depth of the precut hole 522 may be extended down to the throughhole 412 in the circuit board 41 so as to communicate with the same, ordown to the electrical connection pieces 54 of the patch body 5. Afterthe implant assembly 3 is assembled to the patch body 5, the conductivemember 32 is embedded in the precut hole 522, and electrically connectswith the electrical connection pieces 54. The mounting of the implantassembly 3 on the patch assembly 2 similarly uses the external insertiondevice 90 (see FIG. 8) or the guide needle 901 for manual mounting.Since the mounting method is identical to that of the first embodiment,a detailed description thereof is omitted herein for the sake ofbrevity. Moreover, to enhance the sealing effect of the elasticphysiological patch 100″, a sealing member (not shown) may be added forsealing the precut hole 522. For example, a sealing member (not shown)may be added and provided on the signal output end 312 of the sensor 31for contacting or not contacting the conductive member 32. When theimplant assembly 3 passes through the precut hole 522 and enters thepatch body 5, the conductive member 32 and the sealing member are bothembedded in the precut hole 522 to achieve a good sealing effect.However, this disclosure is not limited to the aforesaid example, thesealing member may be added to seal the precut hole 522 after theimplant assembly 3 extends into the patch body 5.

Thus, the third embodiment can similarly achieve the same effect as thatof the first embodiment. Further, because the patch body 5 is formedwith the precut hole 522, during mounting of the implant assembly 3,there is no need for the guide needle 901 to pierce through the top wall52 of the patch body 5, so that the mounting resistance is small.

Referring to FIGS. 15, 16A, 16B, 17A and 17B, the fourth embodiment ofthe elastic physiological patch (100 a) according to this disclosure issuitable for use in delivering drugs to the human body. In thisembodiment, the structure of the patch body 5 is generally identical tothat of the second embodiment, but not the structures of the implantassembly 3 and the electronic device 4.

In the fourth embodiment, the implant assembly 3 does not have theconductive members 32 (see FIGS. 11A to 11C), and the implant 31 is acannula having a tube diameter smaller than 0.5 mm. The insertion device33 is generally identical to that of the second embodiment, and onlydiffers in that a cannula seat 339 is further provided on the track 333.The implant or cannula 31 is disposed on the cannula seat 339. The guideneedle 332 disposed on the movable seat 334 extends through the cannula31. When the movable seat 334 is released to move along the track 333,the cannula seat 339 will move accordingly. At this time, the guideneedle 332 is used to pierce through the bottom wall 51 of the patchbody 5 and the skin of the human body. Finally, the movable seat 334 ispulled back to its original position, which in turn retracts the guideneedle 332 for leaving the cannula 31 implanted in the skin of the humanbody. At the same time, the cannula seat 339 is clamped and positionedby two clamping pieces 330 of the insertion device 32 so as to fix theposition of the cannula 31.

The electronic device 4 of this embodiment does not include thetransmitting unit 42 (see FIG. 4), but includes a liquid drug pump 44,and an electronic control unit 45 for controlling the operation of theliquid drug pump 44. The liquid drug pump 44 is connected to a storageunit 6 disposed in the chamber 53 for delivering liquid drug stored inthe storage unit 6 to the cannula 31 and into the human body. In thisembodiment, the storage unit 6 is a soft storage bag for storing theliquid drug.

The fourth embodiment similarly has the advantages of convenient use andwaterproof effect. Further, the making of the fourth embodiment onlyneeds one time injection of silicone to encapsulate the implant assembly3, the electronic device 4 and the storage unit 6, so that themanufacturing method thereof is simple.

Referring to FIG. 18, the fifth embodiment of the elastic physiologicalpatch (100 b) according to this disclosure is generally identical to thefourth embodiment, and differs in that the patch assembly 2 of thefourth embodiment further includes a hard shell 7. The hard shell 7 isencapsulated by the patch body 5 and is received in the chamber 53. Thehard shell 7 defines a receiving space 72 for receiving the implantassembly 3, the electronic device 4, and the storage unit 6, and has anopening 71 for allowing the cannula 31 to pass therethrough.

The material of the hard shell 7 may be selected from the groupconsisting of acrylonitrile-butadiene-styrene copolymer (ABS),polycarbonate (PC), polypropylene (PE), polyether ether ketone (PEEK),polyterephthalic acid ethylene glycol (PET), polymethyl methacrylate(PMMA), polyoxymethylene (POM), polyvinyl chloride (PVC), chlorinatedpolyvinyl chloride (CPVC), polytetrafluoroethylene (PTFE), nylon,phenolic resin (PF), glass fiber (FRP), and a combination thereof.

In the making of the fifth embodiment, the hard shell 7 is first made,after which the storage unit 6, the electronic device 4, and the implantassembly 3 are placed in an interior space of the hard shell 7, and thenfollowed by wrapping the elastomer around the hard shell 7 to form thepatch body 5.

Thus, the fifth embodiment not only has the effects of the fourthembodiment, in comparison with the conventional hard structurewaterproof process, the fifth embodiment only makes changes to thestructural design with its outer portion being covered by the soft patchbody 5. Hence, this embodiment has a waterproof effect, and themanufacturing process is simple.

Referring to FIG. 19, the sixth embodiment of the elastic physiologicalpatch (100 c) of the present disclosure is generally identical to thefifth embodiment, and differs in the structure of the hard shell 7. Inthis embodiment, the hard shell 7 cooperates with the circuit board 41to define a receiving space 72′ for receiving the cannula 31, thestorage unit 6 and the other components of the electronic device 4, forexample, the liquid drug pump 44, the electronic control unit 45, etc.The sixth embodiment not only has the effects of the fifth embodiment,but also provides another structure of the hard shell 7 for a user toselect according to his/her requirement.

In sum, the patch assembly 2 can press tightly against the implantassembly 3 to achieve waterproof and sealing effects, therebyeffectively protecting the electronic device 4 in the interior portionthereof. Therefore, the object of this disclosure can indeed beachieved.

In the description above, for the purposes of explanation, numerousspecific details have been set forth in order to provide a thoroughunderstanding of the embodiment. It will be apparent, however, to oneskilled in the art, that one or more other embodiments may be practicedwithout some of these specific details. It should also be appreciatedthat reference throughout this specification to “one embodiment,” “anembodiment,” an embodiment with an indication of an ordinal number andso forth means that a particular feature, structure, or characteristicmay be included in the practice of the disclosure. It should be furtherappreciated that in the description, various features are sometimesgrouped together in a single embodiment, figure, or description thereoffor the purpose of streamlining the disclosure and aiding in theunderstanding of various inventive aspects.

While the disclosure has been described in connection with what areconsidered the exemplary embodiments, it is understood that thisdisclosure is not limited to the disclosed embodiments but is intendedto cover various arrangements included within the spirit and scope ofthe broadest interpretation so as to encompass all such modificationsand equivalent arrangements.

What is claimed is:
 1. An elastic physiological patch comprising: apatch assembly including an electronic device, and a soft patch bodyencapsulating said electronic device and defining a chamber forreceiving said electronic device, said soft patch body having a bottomwall which has an adhering surface for being adhered to the skin of asubject; and an implant assembly mountable to said electronic device andincluding an implant; wherein said implant is capable of being driven topartially pass through said patch body and is adapted to be implanted inthe skin of the subject; and wherein said patch body tightly holds saidimplant when said implant is inserted therethrough and cooperates withsaid implant to seal said chamber.
 2. The elastic physiological patch asclaimed in claim 1, wherein said implant assembly is disposed in saidchamber and further includes an insertion device having a guide needle,said implant being detachably positioned in said guide needle, saidguide needle being operable to guide said implant to pass through saidpatch body therealong, and being retractable into said chamber forleaving said implant in the skin of the subject.
 3. The elasticphysiological patch as claimed in claim 1, wherein a guide needle isoperable to guide said implant assembly to pass through said patch bodyfrom an outer side of said patch assembly, and said implant isdetachably disposed in said guide needle.
 4. The elastic physiologicalpatch as claimed in claim 1, wherein said electronic device includes atransmitting unit, and said implant is a sensor.
 5. The elasticphysiological patch as claimed in claim 4, wherein said patch body hastwo spaced-apart electrical connection pieces for electricallyconnecting said electronic device to said sensor, each of saidelectrical connection pieces containing a conductive material.
 6. Theelastic physiological patch as claimed in claim 4, wherein said patchbody has two spaced-apart electrical connection pieces, said sensorhaving a signal output end, said implant assembly further including aconductive member disposed on said signal output end and electricallyconnecting with said electrical connection pieces, said conductivemember being embedded in said patch body.
 7. The elastic physiologicalpatch as claimed in claim 6, wherein said patch body further has abottom wall, and a top wall opposite to said bottom wall and cooperatingwith said bottom wall to define therebetween said chamber, said top wallhaving a precut hole, said conductive member being embedded in saidprecut hole, said precut hole having a diameter smaller than an outerdiameter of said conductive member.
 8. The elastic physiological patchas claimed in claim 7, wherein the outer diameter of said conductivemember is larger than the diameter of said precut hole by 0.1 mm to 1mm.
 9. The elastic physiological patch as claimed in claim 1, whereinsaid implant is a cannula, said patch assembly further including astorage unit for storing liquid drug, said electronic device including aliquid drug pump adapted to deliver the liquid drug stored in saidstorage unit to said cannula.
 10. The elastic physiological patch asclaimed in claim 9, wherein said patch assembly further includes a hardshell that is encapsulated by said patch body, that is received in saidchamber, that defines a receiving space for receiving said storage unitand said electronic device, and that has an opening for allowing saidcannula to pass therethrough.
 11. The elastic physiological patch asclaimed in claim 9, wherein said electronic device further includes acircuit board having a through hole for allowing said cannula to passtherethrough, said patch assembly further including a hard shellreceived in said chamber and cooperating with said circuit board todefine a receiving space for receiving said cannula, said storage unitand said liquid drug pump.
 12. The elastic physiological patch asclaimed in claim 9, wherein said electronic device further includes anelectronic control unit for controlling the operation of said liquiddrug pump.
 13. The elastic physiological patch as claimed in claim 1,wherein said patch body has an adhering surface for being adhered to theskin of the subject, and a plurality of long-strip grooves radiallyformed in said adhering surface.
 14. The elastic physiological patch asclaimed in claim 1, wherein said patch body is made of an elastomerhaving an injection temperature ranging from 140 to 170° C.
 15. Theelastic physiological patch as claimed in claim 14, wherein theelastomer is selected from a group consisting of silica gel, silicone,polyurethane (PU), and a combination thereof.
 16. The elasticphysiological patch as claimed in claim 1, wherein said patch body has abottom wall with a thickness ranged from 0.2 mm to 1 mm.
 17. An elasticphysiological patch comprising: a patch assembly including an electronicdevice, and a soft patch body having a bottom wall which has an adheringsurface for being adhered to the skin of a subject, and a top wallopposite to said bottom wall and cooperating with said bottom wall todefine a chamber for receiving said electronic device; and an implantassembly mountable to said electronic device and including an implant;wherein said implant is capable of being driven to partially passthrough said patch body and is adapted to be implanted in the skin ofthe subject; and wherein, when said implant is implanted in the skin ofthe subject, said top wall is free of any opening and said bottom walltightly holds said implant and cooperates with said implant to seal saidchamber.
 18. The elastic physiological patch as claimed in claim 17,wherein said bottom wall has a thickness ranged from 0.2 mm to 1 mm. 19.The elastic physiological patch as claimed in claim 17, wherein saidsoft patch body encapsulates said electronic device.
 20. The elasticphysiological patch as claimed in claim 17, wherein said implantassembly is disposed in said chamber and further includes an insertiondevice having a guide needle, said implant being detachably positionedin said guide needle, said guide needle being operable to guide saidimplant to pass through said patch body therealong, and beingretractable for leaving said implant in the skin of the subject.